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| Model | Years | Speeds | Drive Train | Trans Model |
| Sequoia Limited, SR5 | 2001-2004 | 4 Spd | RWD, 4WD 4.7L V8 | A340E, A340F |
| Sequoia Limited, SR5 | 2005-2009 | 5 Spd | RWD, 4WD 4.7L V8 | A750E, A750F |
| Sequoia Platinum | 2008-2012 | 6 Spd | RWD, 4WD 5.7L | AB60E, AB60F |
| Sequoia Limited, SR5 | 2010-2019 | 6 Spd | RWD, 4WD 4.6L V8 | A760E, A760F/H |
| Sequoia Limited, SR5, Platinum, TRD Sport, TRD Sport, Nightshade | 2013-2022 | 6 Spd | RWD, 4WD 5.7L V8 | AB60E, AB60F |
| Sequoia Hybrid, Capstone, Limited, Platinum, SR5. TRD Pro, 1794 Edition | 2023-25 | 10 Spd | RWD, 4WD 3.4 Liter V6 Turbo FULL HYBRID EV-Gas | L4A0E, L4A0F |